GS-1500 (Glucosamine Sulfate 1500 mg) 30 Packets Unflavored

The glucosamine sulfate in GS-1500 is up to 98% absorbable, which makes it more readily available to the body to support healthy articular cartilage.
Clinical studies show it's a key building block for connective tissue and cartilage.
Glucosamine Sulfate is clinically studied to build cartilage, and now comes in an easy-to-use, dissolvable powder.
One packet, mixed once a day with water or your favorite beverage, is all you need for optimum joint support.

 

Osteoarthritis (OA) is a slowly progressive disease characterized by a continual breakdown of articular cartilage. The joints most often affected by OA are the knees, hips, spine, and hands. Clinical manifestations of OA include pain, stiffness, and decreased range of motion of the affected joints.

Glucosamine is an aminomonosaccharide, a product of the addition of an amino group to glucose. It occurs naturally in the body. Glucosamine is a basic building block for the biosynthesis of glycosaminoglycans (GAGs) and proteoglycans (PGs) (giant molecules with many GAGs attached), which are important constituents of the articular cartilage.  It also is required for the formation of lubricants and protective agents for the joints. Glucosamine has been reported to stimulate PGs synthesis in articular cartilage, inhibit degradation of PGs, and provide the building blocks to maintain healthy cartilage and joints.

Glucosamine sulfate is the sulfate salt of glucosamine. In solution or in the human body, glucosamine sulfate dissociates into glucosamine and sulfate ions. The sulfate moiety plays an important role in the synthesis of PGs, because the constituent GAGs are highly sulfated. Depletion of sulfate leads to decreased synthesis of GAGs, and sulfate administration counteracts the deleterious effect of sulfate depletion.

Glucosamine sulfate is highly hygroscopic, which means it attracts and absorbs water very easily, by nature. The amino group in the molecule is likely to be oxidized, which causes degradation of the molecule, if it is not stabilized by sodium and chloride. This constitutes a non-hygroscopic substance, which is stable at normal temperature and relative humidity. To date, more than 20 clinical studies using glucosamine sulfate have been reported, with nearly 3,000 patients receiving either glucosamine sulfate or placebo. These studies show a favorable response to glucosamine sulfate vs. placebo in supporting healthy joint function